He greatly advanced the cause of the amelioration of the condition of the insane, and devoted himself largely to the York Retreat. The methods of treatment pursued there were made more widely known by his Description of the Retreat near York. In this work Samuel Tuke referred to the Retreat's methods as moral treatment, borrowed from the French "traitement moral" being used to describe the work of Jean-Baptiste Pussin and Philippe Pinel in France (and in the original French referring more to morale in the sense of the emotions and self-esteem, rather than rights and wrongs).
Samuel Tuke also published Practical Hints on the Construction and Economy of Pauper Lunatic Asylums (1815). :182
He married Priscilla Hack, the daughter of James Hack of Chichester and Hannah Jeffreys.
- James Hack Tuke (1819–1896), also active in humanitarian concerns
- William Murray Tuke (1822–1903), tea merchant and banker
- Daniel Hack Tuke (1827–1895), also active in humanitarian concerns
The Retreat still provides mental healthcare for the population of York and the wider community. Samuel Tuke is buried in the Quaker cemetery within the hospital grounds. In August 2017 York Civic Trust commemorated him with a blue plaque.
- Tuke, Samuel  (1996). Description of the Retreat. London: Process Press. ISBN 1-899209-04-2.
- Sixth Report of the Committee of the African Institution. London: African Institution. 1812.
- "Tuke, Samuel (1784–1857) (DNB00)". DNB. Retrieved 7 August 2015.
- Ross, Alex (27 August 2017). "Blue plaque for mental health reformer". York Press. Retrieved 10 September 2017.