Sande Zeig is from New York City and is of Jewish heritage. She studied theater in Wisconsin and Paris. In 1975, Zeig was living in Paris, studying mime and teaching karate, when she met the writer Monique Wittig. Zeig's 2000 film, The Girl is based on a short story by Wittig. Her 2008 biographical film Soul Masters: Dr. Guo and Dr. Sha follows the work of two Chinese healers, one of whom had previously treated Zeig's father. Zeig is the founder of New York City film distribution company Artistic License Films.
- Central Park (1994)
- The Girl (2000)
- Soul Masters: Dr. Guo and Dr. Sha (2008)
- Apache 8 (2011)
- Sister Jaguar's Journey (2015)
- Lesbian Peoples: Material for a Dictionary (Brouillon pour un dictionnaire des amantes) — coauthored with Monique Wittig
- List of female film and television directors
- List of lesbian filmmakers
- List of LGBT-related films directed by women
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