An original palace at the site was built by the aristocratic Cusani family. The structure was rebuilt and redesigned first in 1776 by Giuseppe Piermarini in a Neoclassical style. In 1817, the villa was sold to the lawyer Giovanni Traversi; beginning in 1840, the interiors were refurbished and the façade added by Pelagio Palagi. The palace has extensive gardens, designed in a free nineteenth century "English style". In 1900, the Villa became property of Tommaso Tittoni, a statesman and diplomat. After World War II, the house functioned as a seminary, until, in 1975, it was acquired by the comune of Desio.
The villa now hosts a library and museum, named after Giuseppe Scalvini.