Thomas Shirley was an English adventurer.
Thomas Shirley is also the name of:
- Thomas Shirley (died 1544), MP for Steyning
- Thomas Shirley (1542–1612), English knight
- Sir Thomas Shirley, 1st Baronet (1727–1800), colonial head of the Bahamas, Governor of the Leeward Islands
- Thomas Shirley (Royal Navy officer) (1733–1814), leader of Shirley's Gold Coast expedition
- Thomas Shirley (RAF officer) (died c.1982), British air marshal
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