He was the son of Thomas Humphrey Lowe and Lucy Hill, daughter of Thomas Hill. He matriculated at Trinity College, Oxford in 1799, graduating B.A. in 1803, and M.A. in 1805. In 1804 he entered Lincoln's Inn.
Lowe was a curate at Shelsley Beauchamp, Worcestershire, in 1810. In 1812 he had a post as domestic chaplain with Henry Hall Gage, 4th Viscount Gage, and in 1814 another curacy, at Diddlebury in Shropshire. In 1820 he became vicar of Grimley, Worcestershire. He was rector of Holy Trinity, Exeter from 1837 to 1840, and Dean of Exeter from 1839 for the rest of his life.
He published in 1825 An essay on the absolving power of the Church.
- Lucy (died 1865 at age 56), married in 1828 Rev. Thomas James Rocke, as his first wife
- Helen (died 1881 at age 72), unmarried
- Thomas Lowe (born 1811, died in Australia)
- George Lowe (1813–1885), cleric, married 1842 Louisa, youngest daughter of Thomas Crookenden of Rushford Hall, Suffolk
- Arthur Lowe (1814–1882), naval officer, married: 1848 Katharina Ommaney, youngest daughter of John Acworth Ommanney R.N.; 1858 Florence Strode, younger daughter of George Strode of Newnham Park, Devon; 1864 Elizabeth Henrietta, eldest daughter of Henry Ducie Chads, R.N.
- Herbert Lowe, baptised 1816
- Noel Lowe (1817–1857), cleric, married 1847 Louisa Julia, younger daughter of John Moore-Stevens of Winscott, Devon
- Anna, baptised 1819, died unmarried 1880
- Emma, baptised 1821, died unmarried 1892
- Harriet, baptised 1822, died unmarried 1898.
- Burke, John (1838). A Genealogical and Heraldic History of the Commoners of Great Britain and Ireland, Enjoying Territorial Possessions Or High Official Rank: But Univested with Heritable Honours. H. Colburn. pp. 38–9. Retrieved 12 November 2017.
- s:Alumni Oxonienses: the Members of the University of Oxford, 1715-1886/Lowe, Thomas (Hill Peregrine Furye)
- List to Deans to 1839 Archived 9 May 2008 at the Wayback Machine
- The Times, Monday, 2 Sep 1839; pg. 4; Issue 17136; col E "Dr. Lowe was confirmed as Dean of Exeter on Friday, and enthroned on Saturday last.-Hereford Journal"
- The Times, Wednesday, 3 Jul 1861; pg. 6; Issue 23975; col A From the LONDON GAZETTE of Tuesday, 2 July. Whitehall, 1 July
- Persons: Lowe, Thomas Hill (1810–1834) in "CCEd, the Clergy of the Church of England database" (Accessed online, 12 November 2017)
- Lowe, Thomas Hill (1825). An essay on the absolving power of the Church. At the University Press for the author. Retrieved 12 November 2017.
- Crisp, Frederick Arthur (1917). "Visitation of England and Wales". Internet Archive. p. 119. Retrieved 12 November 2017.
- Crisp, Frederick Arthur (1909). "Visitation of England and Wales". Internet Archive. pp. 149–53. Retrieved 12 November 2017.
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