Cartwright became a Liveryman of the Masons' Company and has worked in London on numerous buildings in the aftermath of the Great Fire of London of 1666. He was a contractor for St Antholin, St Benet Fink, and St Mary le Bow, three of the Wren churches. He worked as an architect on the Royal Exchange, with sole charge after Edward Jerman died in 1668. He was the architect employed by Sir Robert Clayton, president of the St Thomas' Hospital, to rebuild and the hospital and nearby St Thomas Church on St Thomas Street, SE1, on what is now the site of London Bridge Station.
- Rogers, Nicholas. "Charles, Nicholas". Oxford Dictionary of National Biography (online ed.). Oxford University Press. doi:10.1093/ref:odnb/5150. (Subscription or UK public library membership required.)
- Howard Colvin (1978). A Biographical Dictionary of British Architects 1600–1840. John Murray. p. 201. ISBN 0-7195-3328-7.
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