The Grand Design or some variant thereof may refer to:
The Grand Design
- "The Grand Design" (Yes, Prime Minister), an episode of the BBC television series Yes, Prime Minister
- The Grand Design (album), a 2006 album by Edenbridge
- The Grand Design (book), a book by Stephen Hawking and Leonard Mlodinow
- "Evolution (The Grand Design)", a song by Symphony X from their 2000 album V: The New Mythology Suite
- Grand design spiral galaxy, a type of spiral galaxy
- Program for Action, a New York City Subway expansion plan also called the "Grand Design"
- Grand Designs, a British TV show
- "Grand Designs", a song by Rush from their 1985 album Power Windows
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