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She was born in Guwahati, Assam, India, with Azamgarh origin, and was brought up in Delhi where she completed her schooling and graduated from Delhi university. She joined the National School of Drama, Delhi.
Azmi joined Asmita theatre group, Delhi in 1996. Her plays include Girish Karnad's Rakt Kalyan (Taledanda), Mahesh Dattani's Final Solutions, Ek Mamooli Aadmi, Swadesh Deepak's Court Martial, and Dario Fo's Accidental Death of an Anarchist.
|2005||Water||Deepa Mehta||Bahu- Rani |
|2007||Chak De! India||Shimit Amin||Rani Dispotta|
|2008||Saas Bahu Aur Sensex||Shona Urvashi||Lata K. Kodialbal|
|2011||The Best Exotic Marigold Hotel||John Madden||Anokhi|
|2011||Aarakshan||Prakash Jha||Shambhu Yadav's Wife|
|2014||Sound of Silence: The Collision of Storms Within (Short)||Vipin Paraashar||The Girl|
|2015||Chitrafit 3.0 Megapixel||Divakar Ghodake||Shavla|
|2015||The Second Best Exotic Marigold Hotel||John Madden||Anokhi|
|2018||Mohalla Assi||Dr. Chandraprakash Dwivedi||Ramdayi|
- Dr. Ratan Bhattacharjee (15 August 2012). "Seema Azmi: An Actress with a Difference". Retrieved 11 September 2016.
- National School of Drama Alumni List For The Year 2001 Archived 12 October 2007 at the Wayback Machine
- Dipanita Nath (6 April 2010). "To Sara, with Love". The Indian Express. Retrieved 11 September 2016.
- Prominent Actor's of Asmita theatre