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The Valley is cut in the middle by NYS Route 30.
The Schoharie Valley was famous for its role in the American Revolution. Battles in the Valley included those in Breakabeen, at the Old Stone Fort, and the Battle of the Lower Fort. The Valley was ransacked by Tories and loyal Indian forces during the latter portion of the war.
The Schoharie Valley's main fortress, the Old Stone Fort was used as an armory during the American Civil War.
Today, the prime industry of the Schoharie Valley is farming. The NYS Power Authority also has a hydroelectric power plant in Blenheim, New York. There is also some tourism, primarily to the Old Stone Fort, Dr. Best Museum, Vroman's Nose, and the Old Blenheim Bridge.
- Timothy Murphy, Revolutionary War Hero.
- William C. Bouck, New York Governor.
- Gabriel Bouck, Wisconsin Congressman.
- Joseph Bouck, New York Congressman.
- John McGiver, actor.
- Nicole Sullivan, actress.