|Location||W of U.S. 220, near Fincastle, Virginia|
|Area||35 acres (14 ha)|
|Architectural style||Greek Revival|
|NRHP reference No.||74002107|
|Added to NRHP||July 24, 1974|
|Designated VLR||January 15, 1974|
Santillane is a historic home located near Fincastle, Botetourt County, Virginia. It was built in 1795, and consists of a two-story high, three bay by four bay, main block with a one-story, rear kitchen wing. It is constructed of brick and is in the Greek Revival style. The house has a shallow hipped roof and tetrastyle two-story front portico dated to the early 20th century. Also on the property is a contributing stone spring house. The house stands on a tract purchased by Colonel George Hancock (1754–1820) in 1795. The kitchen wing may date to his period of ownership.
- "National Register Information System". National Register of Historic Places. National Park Service. July 9, 2010.
- "Virginia Landmarks Register". Virginia Department of Historic Resources. Retrieved 2013-05-12.
- Virginia Historic Landmarks Commission Staff (December 1973). "National Register of Historic Places Inventory/Nomination: Santillane" (PDF). Virginia Department of Historic Resources. and Accompanying photo
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