Santa Fe Trail is a historic 19th century transportation route.
Santa Fe Trail may also refer to:
- Santa Fe Trails, the local transit authority in Santa Fe, New Mexico
- Santa Fe Trail (film), 1940
- Santa Fe Trail (short subjects) a 1943–1945 Warner Bros short subjects Western series with Robert Shayne
- The Santa Fe Trail (1923 film), a 1923 Western film serial
- The Santa Fe Trail (1930 film), a 1930 American pre-Code western film
- New Santa Fe Trail, an auto trail
- Santa Fe Trail problem, genetic programming exercise
| This disambiguation page lists articles associated with the title Santa Fe Trail.
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