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Highway-Route 412 (Hebrew: כביש 412), is a regional road in the south-east of the Tel Aviv Metropolitan Area in Israel. The road connects Bilu Junction south of Rehovot, with Yehud Ma'arav Junction, running through Rehovot, Ness Ziona, Rishon LeZion and Beit Dagan and spanning a distance of approximately 22 km.
For most of its length, Route 412 is an urban road, widely changing its width depending on available urban space. Its urban sections are usually very busy, passing through the crowded city centers of Rehovot, Ness Ziona and Rishon LeZion with many signaled intersections.
Route 412 starts at Bilu Junction, a large intersection with Highway 40, making it the central entrance to Rehovot from the south. It runs north as a four-lane (two lanes in each direction) divided urban road until it reaches central Rehovot, where it narrows in size to one lane in each direction. Leaving the city center, it once again widens to four lanes until it reaches a level crossing with the Lod - Ashkelon Railway, just west of the Rehovot Railway Station. It then widens to five lanes (three northbound, two southbound) as it leaves Rehovot.
Entering Ness Ziona, there is a large junction with Road 4303 leading towards Highway 42. The road passes through Ness Ziona as a four-lane divided urban road. Exiting Ness Ziona, HaRishonim Interchange connects the road with Route 431.
Passing through Rishon LeZion, the road varies in length between five (three northbound, two southbound) to six lanes, with the right lane serving as a public transportation lane during rush hours. Exiting Rishon LeZion, the road reaches Beit Dagan Junction with Highway 44.
From Beit Dagan Junction, Route 412 becomes a standard inter-city highway, with two lanes in each direction, paved shoulders, a concrete median barrier and few signaled intersections. The road bypasses Beit Dagan and Or Yehuda to its terminus at Yehud Ma'arav Junction, the south-western entrance to Yehud.
A road bridge designed to replace the over-crowded railway crossing in Rehovot is currently under construction. The bridge will be built by the Ayalon Highway Company and it is due for completion in 2014.
A dedicated bus rapid transit route is planned along the urban section of Route 412, between Bilu Junction and Beit Dagan Junction, as part of a larger mass-transit system designed to serve the entire Tel Aviv Metropolitan Area. From Beit Dagan Junction, the BRT route will continue north-west along Highway 44 to its terminus at Holon Interchange, where it will meet the Green Line of the Tel Aviv Light Rail.