The show features a hillbilly cat called Punkin' Puss (voiced by Allan Melvin) who lives in a house in the woods of the southern US. Punkin' is preoccupied with a hillbilly mouse called Mushmouse (voiced by Howard Morris) who lives there too, and Punkin' frequently tries to shoot him with his rifle.
The "Nowhere Bear" has Punkin' Puss continually disrupting an angry bear's sleep. The episode "Small Change" has Punkin' Puss (and later a dog as well) shrinking to mouse size.
Usually one of Mushmouse's cousins comes and gives Punkin' Puss a hard time. Many would think Punkin' Puss would stop bullying Mushmouse when this occurs but to no avail on Mushmouse's behalf when the relative leaves.
|1||Callin' All Kin||Tired of Punkin's constant attempts to nail him, Mushmouse summons his family, who confuse Punkin' because of their lookalike appearances.||Credited Animator: Carlo Vinci|
|2||Small Change||Mushmouse mixes an enlarging draught which does the opposite of its intended purpose. Punkin' accidentally drinks the draught and faces a difficult fight with Mushmouse, followed by a shrunken hound dog.||Credited Animator: ?|
|3||Hornswoggled||Mushmouse helps a hound dog from a sticky situation and in return he offers to come and help Mushmouse with Punkin'. In response, Punkin' gets his own ally, a skunk called Stanky.||Credited Animator: ?|
|4||Muscle Tussle/Gall of the wild (working/alt.title)||Mushmouse is in despair when his cousin Megaton Mouse comes by. Megaton drives Punkin' mad with a lookalike appearance to Mushmouse but unbelievable strength.||Credited Animator: Carlo Vinci|
|5||Cat Nipped||A stranded Lion is invited by Mushmouse to stay with him and Mushmouse keeps him out of Punkin' and Harmony Sue's sight. The Lion beats Punkin' eventually forcing him out of the house.||Credited Animators: Don Patterson, Dick Lundy, Ed Parks|
|6||Army Nervy Game||After several close shaves from Punkin', Mushmouse leads the US Army to intimidate Punkin' to the point of surrendering.||Credited Animators: Hugh Fraser, Carlo Vinci|
|7||Seein' Is Believin'||Punkin' takes Mushmouse to the Hog Wallow Research Institute for some cash. An experiment turns Mushmouse invisible, giving him a tremendous advantage over Punkin' until it wears off.||Credited Animator: George Nicholas|
|8||Courtin' Disaster||Mushmouse is going courting. Mushmouse, determined to please Hunnybun, confronts Punkin'. All that keeps Mushmouse going is Hunnybun's incentive kiss until Mushmouse finds his girlfriend after his favours.||Credited Animators: Hugh Fraser, Carlo Vinci|
|9||A Tale Of Two Kitties||Punkin' and his new neighbour Tennessee Tabby fight over who gets to pin down Mushmouse. Mushmouse sneakily tips the two cats with methods on getting at each other until they find out they've been duped.||Credited Animators: Carlo Vinci, Hugh Fraser|
|10||Chomp Romp||Mushmouse receives a package containing a remote controlled mechanical watchdog. After assembling it, Mushmouse names it Chomper. Punkin's efforts against the Chomper are futile even when he blows it up.||Credited Animators: Carlo Vinci, Hugh Fraser|
|11||Catch As Cat Can Day||Today is the day a gal catches a guy. Susie McStomp goes after Punkin' while Mushmouse gives away Punkin's every hiding place to Susie. Mushmouse gets into a similar chase with Hunnybun.||Credited Animators: George Goepper, Kenneth Muse|
|12||Jump Bumps||Mushmouses' attempts to beat Punkin' with fitness don't work, so he orders a boxing kangaroo named Hunka Hunka. Punkin' mistakes Hunka Hunka for a very fit Mushmouse and fails every time to beat him.||Credited Animators: Carlo Vinci, Hugh Fraser|
|13||Nowhere Bear||Mushmouse gets chased by Punkin' to a sleeping bear who doesn't like to be disturbed. Mushmouse gets Punkin' repeatedly in a punch up with the bear, until he gets annoyed and keeps Punkin' tied up.||Credited Animators: Dick Lundy, William Keil|
|14||Legend Of Bat Mouseterson||Mushmouse's cousin Bat Mouseterson arrives for a visit. Mouseterson hits Punkin' for every rude action he resorts to. When Mouseterson has to leave, Mushmouse has to fend for himself.||Credited Animator: ?|
|15||Super Drooper||Mushmouse tries to contact Super Duper Duper Duper Duper Duper Cat (or Super Duper Duper Etcetera Cat) in hope he'll save him from Punkin'. Punkin' impersonates the superhero until the real one comes to Mushmouses' rescue, but has to leave for Hollywood.||Credited Animators: Dick Lundy, William Keil|
|16||Pep Hep||Mushmouse is about to give up his life of feuding, when a package containing Speedo pills arrives. Those give Mushmouse a great advantage over Punkin'. When Punkin' discovers them, he takes an overdose and becomes completely airborne. Note: This episode was eventually removed from circulation, as it showed drug abuse.||Credited Animator: ?|
|17||Shot At And Missed||Unable to take more of Punkin's chases, Mushmouse heads off to town to apply for a job, involving Mouse-O-matics. Finding himself worse off without Mushmouse, Punkin' sets off to reclaim him.||Credited Animator: ?|
|18||The Mouse From S.O.M.P.||Mushmouse orders a Mouse From S.O.M.P. Kit, so he can defend himself from Punkin'. Punkin' gets a similar kit to counter Mushmouse getting them evenly matched.||Credited Animator: ?|
|19||Host Of A Ghost||After Mushmouse gets Punkin' knocked out in a feud, he tricks him into thinking he's become a ghost. Mushmouse proceeds to get Punkin' to spoil him, until Punkin' sees through his trick.||Credited Animator: ?|
|20||Feudal Feud||Punkin' Puss gets a knockout, dreaming of the Feudal Age with Saxon mice and their king Mushmouse. Punkin' is faced with Meany Mouse and eventually wakes up from this dream and resumes feuding with Mushmouse.||Credited Animator: ?|
|21||Heir Conditioning||Mushmouse inherits from his late uncle £1000. Punkin' treats Mushmouse better in hope of getting a share. To their surprise the inheritance is one thousand pounds of cheese.||Credited Animator: ?|
|22||Hyde And Shriek||Mushmouse mixes a potion similar to Dr. Jekyll's formula, which turns him into a monstrous mouse. When Punkin' tries it, he unleashes a mean doppelganger of himself.||Credited Animator: ?|
|23||Misfortune Cookie||According to Mushmouse's horoscope book, today is Punkin's unlucky day. Sure enough Punkin' encounters many misfortunes until the next day, which is Mushmouse's turn to face misfortune.||Credited Animator: ?|
- Punkin' Puss can be seen as an animatronic in the Dexter's Laboratory episode "Chubby Cheese".
Punkin' Puss & Mushmouse in other languages
- Brazilian Portuguese: Bacamarte & Chumbinho
- Français: Chat-des-Champs et Souriceau
- Italian: Gatto Bernardo e Topo Didì
- Spanish: El ratón Mush y el Calabaza
- Portuguese: Gato Saloio e o Rato Maloio