Paul Henry de Kruif (//, rhyming with "life") (1890–1971) was an American microbiologist and author of Dutch descent. Publishing as Paul de Kruif, he is most noted for his 1926 book, Microbe Hunters. This book was not only a bestseller for a lengthy period after publication, but has remained high on lists of recommended reading for science and has been an inspiration for many aspiring physicians and scientists.
De Kruif was born March 2, 1890, in Zeeland, Michigan. In 1912, he graduated from the University of Michigan with a bachelor's degree, and he remained there to obtain a Ph.D., which was granted in 1916. He immediately entered service as a Private in Mexico on the Pancho Villa Expedition and afterwards served as a Lieutenant and a Captain in World War I in France. Because of his service in the Sanitary Corps, he had occasional contacts with leading French biologists of the period.
After returning to the University of Michigan as an Assistant Professor, De Kruif briefly worked for the Rockefeller Institute (for Medical Research). He then became a full-time writer.
De Kruif assisted Sinclair Lewis with his Pulitzer Prize-winning novel Arrowsmith (1925) by providing the scientific and medical information required by the plot, along with character sketches. Even though Lewis was listed as the sole author, De Kruif's contribution was significant, and he received 25 percent of the royalties. Many believe the characters in the novel represent people known to De Kruif, with Martin Arrowsmith (a physician, unlike de Kruif) possibly representing himself.
While working for the Rockefeller Institute, De Kruif submitted an anonymous entry about modern medicine, for a book entitled Civilization. In the article, he decried the state of contemporary medical practice, which, because it lacked scientifically sound practices, he called "medical Ga-Ga-ism". De Kruif decried doctors as providing only a "mélange of religious ritual, more or less accurate folk-lore, and commercial cunning". When it was discovered that De Kruif was the author of the essay, he was fired from the Rockefeller Institute.
De Kruif was a staff writer for the Ladies' Home Journal, Country Gentleman, and the Readers Digest, contributing articles on science and medicine. He also served on commissions to promote research into infantile paralysis (polio).
The Sweeping Wind, De Kruif's last book, is his autobiography.
De Kruif died February 28, 1971, in Holland, Michigan.
- Hunger Fighters (1928)
- Seven Iron Men (1929)
- Men Against Death (1932)
- Why Keep Them Alive (1937)
- The Fight for Life (1938)
- The Male Hormone (1945)
- Health is Wealth (1940)
- Life Among the Doctors (1949)
- Kaiser Wakes the Doctors (1940)
- A Man Against Insanity (1957)
- The Sweeping Wind (1962)
Influential articles by Paul de Kruif
- "How We Can Help Feed Europe, in Reader's Digest, Sept. 1945 (p. 50-52). About the Meals for Millions Foundation and their Multi-Purpose Food.
De Kruif's celebrated 1926 book Microbe Hunters consists of chapters on the following figures of medicine's "Heroic Age":
- Anton van Leeuwenhoek (1632-1723), Invention of a simple microscope and the discovery of microorganisms.
- Lazzaro Spallanzani (1729-1799), Biogenesis.
- Robert Koch (1843-1910), Identification of pathogens.
- Louis Pasteur (1822-1895), Bacteria, Biogenesis.
- Emile Roux (1853-1933) and Emil von Behring (1854 -1917), Diphtheria.
- Elie Metchnikoff (1845-1916), Phagocytes.
- Theobald Smith (1859-1934), Animal vectors and ticks.
- David Bruce (1855-1931), Tsetse fly and Sleeping sickness.
- Ronald Ross (1857-1932) and Battista Grassi (1854-1925), Malaria.
- Walter Reed (1851-1902), Yellow fever.
- Paul Ehrlich (1854-1915), The magic-bullet concept applied to syphilis (see the 1940 film Dr. Ehrlich's Magic Bullet).
- Jan Peter Verhave, “Paul de Kruif: A Michigan Leader in Public Health,” Michigan Historical Review, 39 (Spring 2013), 41–69.
- Marantz Henig, Robin. "The Life and Legacy of Paul de Kruif". The Alicia Patterson Foundation. Retrieved 11 May 2018.
- "Our medicine men, by Paul H. De Kruif". HathiTrust. Retrieved March 8, 2020.
- de Kruif, Paul (1926). Microbe Hunters. Blue Ribbon Books. New York: Harcourt Brace & Company Inc. Retrieved May 8, 2020.
- Ulrich, Mabel S. (8 June 1940). "Review: Health Is Wealth by Paul de Kruif". The Saturday Review: 7.
- Summers, William C. "Microbe Hunters revisited", Internatl Microbiol (1998) 1: 65-68. online
- Verhave, Jan Peter, “Paul de Kruif: A Michigan Leader in Public Health,” Michigan Historical Review, 39 (Spring 2013), 41–69.