The younger Gregory worked in various positions at the First National Bank of Mayfield from 1917 through 1936. From 1923 to 1936 he also served as secretary-treasurer of the Mayfield Board of Education.
In 1936 William Voris Gregory was an incumbent already re-nominated by the Democratic Party for re-election in when he died on October 10 of that year. Noble Jones Gregory was nominated for his late brother's seat. In 1936 Gregory was elected to the United States House of Representatives, representing Kentucky's 1st district in the far western part of the state. He was re-elected ten times, serving for 22 years during his eleven terms in the House. At this time, the Democratic primary was the only competitive contest in this part of the state, which overwhelmingly supported Democratic candidates. Most blacks, who had previously supported the Republican Party, were still disenfranchised.
In 1958 Gregory sought re-election to his seat but was defeated in the Democratic primary by Frank Stubblefield; he won the general election. After being defeated, Gregory returned to the banking and investment business in Mayfield. He is buried in Maplewood Cemetery in Mayfield.
- United States Congress. "Noble Jones Gregory (id: G000447)". Biographical Directory of the United States Congress.
|U.S. House of Representatives|
William Voris Gregory
| Member of the U.S. House of Representatives
from Kentucky's 1st congressional district
1937 – 1959