|First meeting||October 6, 1973|
Nicholls State 3, Northwestern State 0
|Latest meeting||October 6, 2018|
Nicholls 28, Northwestern State 10
|All-time series||Northwestern State leads, 28–17|
|Largest victory||Nicholls State, 58–0 (2007)|
|Longest win streak||Northwestern State, 9 (1980–1988)|
|Current win streak||Nicholls, 3 (2016–present)|
The NSU Challenge is an American college football rivalry game played annually between the Nicholls Colonels football team representing Nicholls State University and Northwestern State Demons football team representing Northwestern State University. Both universities are members of the Southland Conference. The NSU Trophy, which is a wooden trophy enscripted with NSU goes to the winning team.
|Nicholls State victories||Northwestern State victories|
- "Rivalry trophy on the line in road test at Northwestern State". geauxcolonels.com. Retrieved October 7, 2018.
- "Nicholls prepares to face SLC rival Northwestern State". houmatoday.com. October 27, 2012. Retrieved March 21, 2013.
- "Demons hoping to get back in the groove for Homecoming". nsudemons.com. Retrieved June 25, 2015.
- "Demons handled the elements to put away Colonels". desmoinesregister.com. Retrieved October 7, 2018.
- "Colonels to Battle Demons in Rivalry Game". geauxcolonels.com. Retrieved October 7, 2018.
- "Northwestern State vs. Nicholls State - All Time" (PDF). geauxcolonel.com.