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Henry O'Brien, 5th Earl of Thomond (1588 – 26 July 1639) was an Irish peer, styled Lord Ibrickane until 1624.
O'Brien was the son of Donogh O'Brien, 4th Earl of Thomond and Elisabeth FitzGerald. On 13 July 1608 he married Mary Brereton, daughter of William Brereton, 1st Baron Brereton and Margaret Savage, and together they had 5 daughters:
- Lady Margaret O'Brien, who married firstly Edward Somerset, 2nd Marquess of Worcester and secondly Donough Kearney
- Lady Mary O'Brien (d. 1686) married, on 24 June 1627, Charles Cokayne, 1st Viscount Cullen
- Lady Elisabeth O'Brien (d. 1656–1659) married, on 21 August 1636, Dutton Gerard, 3rd Baron Gerard (1613–1640), grandson of Thomas Gerard, 1st Baron Gerard
- Lady Anne O'Brien (d. 1645) married, in 1641, Henry O'Brien, 7th Earl of Thomond
- Lady Honora O'Brien
O'Brien died in 1639, and was succeeded in his peerages by his brother Barnabas O'Brien, 6th Earl of Thomond.
|Peerage of Ireland|
| Earl of Thomond
| Baron Ibrickane|
(writ in acceleration)