Henry Evans Spencer (born June 13, 1807 in Columbia – now part of Cincinnati) was a notable Cincinnati resident and was Mayor of Cincinnati from 1843–1851. He died February 2, 1882 at the age of 74.
Spencer was member of the City Council in Cincinnati for a number of years before becoming Mayor. He was a member of the Whig party, though some years later he became a Democrat. Spencer was succeeded as mayor by Mark P. Taylor in 1851.
- Greve, Charles Theodore (1904). Centennial History of Cincinnati and Representative Citizens. Biographical Publishing Company. p. 654.