During his early career in the church, he was Referendary of the Apostolic Signatura; vice-legate of Bologna; governor of Fano; a cleric in the Apostolic Camera; governor of Rome; and Vice-Camerlengo of the Holy Roman Church.
Pope Alexander VIII named him a cardinal priest in the consistory of February 13, 1690, with dispensation for not having received the minor orders. He received the red hat on April 10, 1690, receiving the titulus of Santa Maria del Popolo at that time. He was then named cardinal protector of Spain. He participated in the conclave of 1691 that elected Pope Innocent XII.
He declined a promotion to the see of Salerno in 1696. He managed Spanish affairs in Rome 1698-99. On March 30, 1700, he transferred Santa Maria del Popolo for Santa Sabina as his titulus. He participated in the conclave of 1700 that elected Pope Clement XI. In December 1701, he became Viceroy and Captain General of the Kingdom of Sicily.
On January 14, 1704, Cardinal Giudice was elected Archbishop of Monreale; he was consecrated as a bishop in the Church of the Gesu in Palermo on February 10, 1704 by Giuseppe Gasch, Archbishop of Palermo, assisted by Annibale Termini, Bishop of Siracusa, and by Bartolomeo Castelli, Bishop of Mazzara.
In 1711, Philip V of Spain named Cardinal Giudice Grand Inquisitor of Spain (in which capacity he was the head of the Spanish Inquisition); he was commissioned as Grand Inquisitor on June 11, 1711. He briefly lost royal favor in July 1714 when he issued an edict condemning certain regalist writings into exile at Bayonne, but he was allowed to return to Spain later that year following the death of Maria Luisa of Savoy and the subsequent loss of influence of Marie Anne de La Trémoille, princesse des Ursins. In 1716, his disagreements with Cardinal Giulio Alberoni ultimately led to his resignation as Grand Inquisitor of Spain.
On July 12, 1717, Cardinal Giudice exchanged his titulus of Santa Sabina for the Suburbicarian See of Palestrina, while retaining his post as Archbishop of Monreale. On August 11, 1719, he became Austria's minister to the Holy See, a post he held until 1720. He also became Secretary of the Roman Inquisition in 1719, a post he held until his death. He exchanged his titular see of Palestrina for the Suburbicarian See of Frascati on March 3, 1721. He participated in the conclave of 1721 that elected Pope Innocent XIII and the conclave of 1724 that elected Pope Benedict XIII. He became Dean of the College of Cardinals on June 12, 1724, exchanging his titular see for the Suburbicarian See of Ostia at that time. He resigned as Archbishop of Monreale on February 15, 1725.
Cardinal Giudice died in Rome on October 10, 1725. His funeral was held at San Marcello al Corso on October 12, 1725, with Pope Benedict XIII in attendance. His remains were then transferred for temporary burial at Santa Maria sopra Minerva before eventually being returned to Naples for permanent burial in Santa Maria del Carmine.
Juan Manuel María de la Aurora, 8th duke of Escalona
| Viceroy of Sicily
1702 - 1705
Isidoro de la Cueva y Benavides
|Catholic Church titles|
Antonio Ibáñez de Riva Herrera
| Grand Inquisitor of Spain
Several Appointed but none serve until Diego de Astorga y Céspedes