Complement-dependent cytotoxicity (CDC) is an effector function of IgG and IgM antibodies. When they are bound to surface antigen, the classical complement pathway is triggered, resulting in formation of a membrane attack complex (MAC) and target cell lysis.
CDC is measured with various assays to evaluate the effect of drug therapies.
This section needs expansion. You can help by adding to it. (February 2016)
- Contrast with antibody-dependent cellular cytotoxicity (ADCC)
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