|Died||February 15, 2011 (aged 77)|
|Alma mater||Central High School (Philadelphia)|
Harvard Medical School
|Known for||Research in Down syndrome|
|Spouse(s)||Lois Epstein, (m.1956-2011, his death)|
|Institutions||University of Washington|
University of California, San Francisco
Buck Institute for Age Research
Charles Joseph Epstein (September 3, 1933 – February 15, 2011) of Tiburon, California, was a geneticist who was severely injured in 1993 when he became a victim of a mail bomb attack by the Unabomber. He was a researcher at the University of California, San Francisco and the Buck Institute for Age Research.
Epstein began his work in medical genetics—the application of genetics research to human care—in a fellowship with Arno Motulsky, one of the founders of medical genetics, at his Seattle University of Washington lab. While there, Epstein worked to understand the nature of Werner's syndrome, a genetic disease that causes premature aging.
He is most notable for conducting groundbreaking research on Down syndrome. In 1967 he became the chairman of the medical genetics division in the pediatrics department of UC San Francisco. He did research on making a mouse model for Down syndrome.
Epstein was the president of the American Society of Human Genetics in 1996 and the editor-in-chief of the American Journal of Human Genetics from 1986 to 1993. (He became the official editor-in-chief on the 1st of July 1986 and was severely injured in June 1993.)
During the last 10 years of his life, Epstein participated in the formation of the Buck Institute located in Novato, California, serving as chairman of its scientific advisory board and board of trustees.
In June 1993 Epstein received a mail bomb sent by Ted Kaczynski, known at the time as the Unabomber. The explosion severed several of Epstein's fingers, caused abdominal injuries, and resulted in a partial loss of his hearing.
- "Charles Epstein, Leading Medical Geneticist Injured by Unabomber, Dies at 77". The New York Times. Retrieved 2016-04-21.
- "North Bay survivor of Unabomber attack dies at 77 - San Jose Mercury News". Mercurynews.com. Retrieved 2016-04-21.
- Fagan, Kevin (2011-02-20). "Dr. Charles Epstein, Down syndrome pioneer, dies". SFGate. Retrieved 2016-04-21.
- "UW Genome Sciences: Arno Motulsky". Gs.washington.edu. Retrieved 2016-04-21.
- Epstein CJ, Graham CB, Hodgkin WE, Hecht F, Motulsky AG (1968). "Hereditary dysplasia of bone with kyphoscoliosis, contractures, and abnormally shaped ears". The Journal of Pediatrics. 73 (3): 379–86. doi:10.1016/s0022-3476(68)80115-5. PMID 5667420.
- Epstein CJ (June 2006). "Down's syndrome: critical genes in a critical region". Nature. 441 (7093): 582–83. doi:10.1038/441582a. PMID 16738647. S2CID 5577410.
- Wynshaw-Boris, Anthony; Risch, Neil; Motulsky, Arno (2011). "Charles Joseph Epstein, M.D., 1933–2011, In Memoriam". The American Journal of Human Genetics. 88 (6): 684–688. doi:10.1016/j.ajhg.2011.05.016. ISSN 0002-9297. PMC 3113342. PMID 21805720. (This obituary contains a typographical error: "seven years (1987–1993)" should be replaced by "seven years (1986–1993)".)
- Cannizzaro, L. A.; Emanuel, B. S.; Cho, K. W.; Weinmann, R. (1986). "The gene encoding the large subunit of human RNA polymerase II is located on the short arm of chromosome 17". American Journal of Human Genetics. 38 (6): 812–818. PMC 1684854. PMID 3460332. (See the New Editor notice on page 818.)
- "Charles Epstein Obituary - San Francisco, CA | San Francisco Chronicle". Legacy.com. Retrieved 2016-04-21.