An ardent advocate for prohibition, in 1944 Johnson was the Prohibition Party's nominee for Vice-President of the United States. The Party, meeting in Indianapolis November 1943 originally named Floyd C. Carrier as its vice presidential candidate. At the time of the nomination, Carrier was serving as general secretary for the American Temperance Society. He subsequently dropped out of the campaign because of health problems. Johnson was added by the party's executive committee to replace him. Johnson and Claude Watson, the party's presidential nominee, actively campaigned throughout the election cycle and were on the ballot in 27 states for the 1944 general election. They received a total of 74,758 votes.
- "Andrew Nathan Johnson". Andrew Nathan Johnson. Retrieved 4 February 2012.
- "Our Campaigns". Johnson, Andrew N. Retrieved 4 February 2012.
- "Ballots Close; Teetotalers Under Line". Eugene Register-Guard. 3 September 1944. Retrieved 4 February 2012.
- "Prohibition Party Names Candidates". Schenectady Gazette. November 13, 1943. Retrieved 4 March 2012.
- Storms, Roger C. (1972). Partisan Prophets: a history of the Prohibition Party 1854-1972. National Prohibition Foundation. p. 51.
- "Prohibition Party". (See Table). eNotes. Retrieved 4 March 2012.
- Storms, Roger C. (1972). Partisan Prophets: a history of the Prohibition Party 1854-1972. National Prohibition Foundation. p. 52.