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She began her professional career as a model. In 1989, she began working as a television presenter, leading "Twelve plus one". In 1996 she participated in a segment of Videomatch, a program run by Marcelo Tinelli, running the hidden cameras. In 1998, Mitchelstein did a prerecorded program, "Viva la Diferencia", a game program that was a success.
As a television actress, she was one of the leads on the successful humor program, broadcast by Telefe during 2001 and 2002, with Guillermo Francella. In 2003 she made special appearances on the comedy Son Amores, and made appearances on the comedy Los Roldán in 2004 and 2005. In the theater, she played in various works, such as "Una Eva y Dos Salames", Money Money, Taxi and others. In 2007, she began working on the broadcast channel, America TV, as host of a question and answer show called "Do you know more than a 5th grader?". In 2007, she hosted every morning of "Hello America" on the Fox Sports channel. In 2009, she made a special appearance on the comedy, The Successful Pells, broadcast by Telefe.
With her beauty, Andrea was the face of several companies and brands for some time. Among the highlights were Cocoto, Impulse, Sedal shampoo, Tofi, Coca-Cola, Quilmes beer, Lux and for years she was the face of Pantene.
- Doce más uno (1989)
- Despertar al país (1991)
- Desfiles Roberto Giordano (1994)
- Videomatch (1996)
- Viva la Diferencia (1998)
- Al que le toca, le toca (2001)
- Poné a Francella (2001 - 2002)
- Mar del Plata Moda Show (2002)
- Una Eva y dos Salames (2003)
- Bingo con Rodolfo Ranni (2003)
- Money Money (2004)
- Los Roldán (2004 - 2005)
- Taxi (2005)
- ¿Sabes más que un chico de 5 grado? (2007)
- Hola América (since 2007)
- Los Exitosos Pells (2009)
- Desearás al hombre de tu hermana (2017)