This article relies largely or entirely on a single source. (April 2016)
Amanieu d'Albret was born in the Kingdom of France ca. 1478, the son of Alain I of Albret, and Frances, Countess of Périgord. His older brother Jean married Catherine of Navarre. His uncle Louis d'Albret was also a cardinal. He had three illegitimate children, one son and two daughters.
On July 19, 1499, he became apostolic administrator of the see of Comminges, but on January 1, 1502, the cathedral chapter of Saint-Bertrand-de-Comminges Cathedral chose another candidate as bishop.
Pope Alexander VI made him a cardinal deacon in the consistory of March 20, 1500. The pope sent him the red hat on October 2, 1500, and he received the deaconry of San Nicola in Carcere on October 5, 1500.
He participated in both the papal conclave of September 1503 that elected Pope Pius III. and the papal conclave of October 1503 that elected Pope Julius II. After this second conclave he had to leave Rome.[why?]
He was administrator of the see of Vannes from January 8 to October 14, 1504; of the see of Bazas from December 4, 1504 until his death; of the see of Lescar from October 6, 1507 until June 20, 1515; and of the see of Pamplona from May 13, 1510 until 1512, and again from 1517 until his death.
He participated in the plot of cardinals against Pope Julius II. In 1511, he attended the schismatic Council of Pisa even after the pope threatened him with excommunication. There, he was a strong supporter of the French party.
After the death of Julius II, he participated in the papal conclave of 1513 that elected Pope Leo X.[contradictory] The new pope absolved Cardinal d'Albret (along with Cardinals Guillaume Briçonnet and René de Prie) and confirmed him in his offices. He also served as administrator of the see of Pamiers from 1514 until his death. He became the cardinal protodeacon on September 3, 1520.