|Dates||28 February - 3 March 2019|
|Defending champions||Perfumerías Avenida|
|Runners-up||Spar CityLift Girona|
The Copa de la Reina de Baloncesto 2019 was the 57th edition of the Spanish Queen's Basketball Cup. It is managed by the Spanish Basketball Federation – FEB and was 28 February to 3 March 2019 in the Polideportivo de Mendizorroza, Vitoria-Gasteiz. Perfumerías Avenida beat Spar CityLift Girona 79-71 in the final. Érika de Souza was the MVP.
Prior to the start of the season, the rules of the Spanish Basketball Federation established that the top seven teams classified after the end of the first half of the 2018–19 League (13th matchday, 30 December 2018), would play the competition along with the host chosen by the Federation.
|1||Spar CityLift Girona||13||12||1||1055||739||+316||25||Qualified as seeded teams|
|3||Lointek Gernika Bizkaia||13||10||3||935||801||+134||23|
|4||Cadí La Seu||13||10||3||892||805||+87||23|
|7||Nissan Al-Qázeres Extremadura||13||6||7||900||898||+2||19|
|9||RPK Araski (H)||13||5||8||803||894||−91||18|
The Cup was drawn on 15 February 2019 in Vitoria-Gasteiz. The seeded teams were paired in the quarterfinals with the non-seeded teams. There were not any restrictions for the draw of the semifinals.
|Spar CityLift Girona||52|
|Spar CityLift Girona||80|
|Cadí La Seu||60|
|Cadí La Seu||66|
|Spar CityLift Girona||71|
|Nissan Al-Qázeres Extremadura||63|
|Lointek Gernika Bizkaia||46|
|Lointek Gernika Bizkaia||83|
- "CALENDARIO: La Liga DIA 2018/19 tiene marcado su camino" (in Spanish). Spanish Basketball Federation. 18 July 2018. Retrieved 22 January 2019.
- "Decididos los emparejamientos de cuartos de la Copa de la Reina 2019" (in Spanish). Spanish Basketball Federation. 15 January 2019. Retrieved 22 January 2019.