|Finals site||Savvis Center|
St. Louis, Missouri
|Champions||Notre Dame Fighting Irish (1st title)|
|Runner-up||Purdue Boilermakers (2nd title game)|
|MOP||Ruth Riley (Notre Dame)|
The 2001 NCAA Division I Women's Basketball Tournament began on March 16 and ended on April 1. The tournament featured 64 teams. The Final Four, held at the Savvis Center (now Scottrade Center) in St. Louis, consisted of Connecticut, Notre Dame, Purdue, and Southwest Missouri State (now Missouri State), with Notre Dame defeating Purdue 68–66 to win its first NCAA title. Notre Dame's Ruth Riley was named the Most Outstanding Player of the tournament.
With the Final Four held in the Missouri for the first time in NCAA history, 10th seeded University of Missouri rose to the occasion and upset 7th seeded Wisconsin in the first round. They then went on to play the 2nd seeded team from Georgia and won that game as well, advancing to the regional, where their bid to play in their home state ended in a loss to Louisiana Tech. Missouri State also did well. They were seeded 5th, so expected to win their first-round game, but they went on to upset 4th seed Rutgers to set up a game against the Regional's top seed, Duke. Missouri State upset Duke 81—71 to head to the regional final against Washington, who had upset both Florida and Oklahoma. The upsets came to an end as 5th seeded Missouri State beat 6th seeded Washington 104–87 to advance to the Final Four, and a chance to play in front of home state fans.
In the Mideast Regional, the top four seeds all advanced to the regional semifinal, then both higher seeds were upset. 4th seed Xavier knocked off the number one seed in the regional, Tennessee, by a score of 80–65. Third seeded Purdue played second seeded Texas Tech in a game that came down to the wire. Purdue won 74–72, then went on to defeat Xavier for the spot in the Final Four against Missouri State. The upset run by Missouri State came to an end in the semifinal, as Purdue beat them 71–64. The career of Jackie Stiles, who had scored 1,064 points during the season, the only player in NCAA Division I women's basketball history to score 1000 points in a season, came to an end.
In the Midwest and East regionals, both number one seeds advanced to the Final Four. Both Notre Dame and Connecticut were from the Big East and met in the other semifinal. The two teams had met twice before in the season, with Notre Dame winning at their home and UConn beating Notre Dame in the Big East Championship. Early in the game, the prior year National Champion Connecticut looked to be on their way to another championship game. The Huskies led at one point by 16 points in the first half. In the second half, Notre Dame came back, and with just over twelve minutes left, took their first lead of the game. Connecticut went into a scoring drought, going more than five minutes without a point. Notre Dame went on to win 90–75, to head to their first national championship game.
The championship game featured two teams from Indiana. Notre Dame began the game with a repeat of their performance against Connecticut, falling behind by double digits in the first half. The Irish were the best three-point shooting team in the country, but ended up hitting just one of ten attempts. Purdue's Katie Douglas scored 18 points for Purdue, with her final points being a three-pointer to put the Boilermakers in front 66–64 with a little over one minute left in the game. Notre Dame's Ruth Riley scored to tie the game, then rebounded a miss by Purdue. She then took a shot, missed, but was fouled with 5.8 seconds left in the game. Riley sank both free throws to give the Irish a two-point lead and their first national championship.
- Three-point field goal percentage—Alicia Ratay, Notre Dame, hit four of five three-point field goal attempts(80%) in the semi-final game against Connecticut, tying a record for three-point field goal percentage in a Final Four game, held by four other players.
- Margin overcome—Notre Dame overcame a 16-point deficit against Connecticut to win the game, setting a record for the largest margin overcome in a Final Four game.
- Three-point field goal percentage—Notre Dame hit eight of eleven three-point field goal attempts, setting the record for best three-point field goal percentage in a Final Four game.
- Blocks—Notre Dame recorded eleven blocks in the championship game against Purdue, tying the record for blocks in a Final Four game.
- Assists—Tasha Pointer, Rutgers, recorded 18 assist in the West region first-round game against Stephen F. Austin, setting the record for most assists in an NCAA tournament game.
- Field goal percentage—Connecticut held Long Island to 10 field goals on 65 attempts(15.4%) in an East region first-round game, setting the record for the best field goal defense in an NCAA tournament game.
Qualifying teams - automatic
Sixty-four teams were selected to participate in the 2001 NCAA Tournament. Thirty-one conferences were eligible for an automatic bid to the 2001 NCAA tournament.
Qualifying teams - at-large
Thirty-three additional teams were selected to complete the sixty-four invitations.
|George Washington||Atlantic 10||22–9||14–2||7|
|Notre Dame||Big East||28–2||15–1||1|
|Penn State||Big Ten||19–9||11–5||6|
|Texas Tech||Big 12||23–6||13–3||2|
|Virginia Tech||Big East||23–6||11–5||7|
Bids by conference
Thirty-one conferences earned an automatic bid. In nineteen cases, the automatic bid was the only representative from the conference. Thirty-three additional at-large teams were selected from twelve of the conferences.
|7||Big 12||Iowa State, Baylor, Colorado, Missouri, Oklahoma, Texas, Texas Tech|
|6||Atlantic Coast||Duke, Clemson, Florida State, Maryland, NC State, Virginia|
|6||Southeastern||Georgia, Arkansas, Florida, LSU, Tennessee, Vanderbilt|
|5||Big East||Connecticut, Notre Dame, Rutgers, Villanova, Virginia Tech|
|5||Big Ten||Iowa, Michigan, Penn State, Purdue, Wisconsin|
|4||Pacific-10||Arizona State, Oregon, Stanford, Washington|
|2||Atlantic 10||Xavier, George Washington|
|2||Conference USA||Tulane, Louisville|
|2||Metro Atlantic||Siena, Fairfield|
|2||Missouri Valley||SW Missouri State, Drake|
|2||Mountain West||Colorado State, Utah|
|2||Sun Belt||Louisiana Tech, Denver|
|1||Big Sky||Idaho State|
|1||Big West||UC Santa Barbara|
|1||Ohio Valley||Austin Peay|
|1||Southland||Stephen F. Austin|
|1||Trans America||Georgia State|
|1||West Coast||St. Mary's Cal.|
First and second rounds
In 2001, the field remained at 64 teams. The teams were seeded, and assigned to four geographic regions, with seeds 1–16 in each region. In Round 1, seeds 1 and 16 faced each other, as well as seeds 2 and 15, seeds 3 and 14, seeds 4 and 13, seeds 5 and 12, seeds 6 and 11, seeds 7 and 10, and seeds 8 and 9. In the first two rounds, the top four seeds were given the opportunity to host the first-round game. In most cases, the higher seed accepted the opportunity. The exception:
- Fourth seeded Iowa was unable to host so fifth seeded Utah hosted three first and second-round games
The following table lists the region, host school, venue and the sixteen first and second round locations:
Regionals and Final Four
The Regionals, named for the general location, were held from March 24 to March 26 at these sites:
- Midwest Regional Pepsi Center, Denver, Colorado (Host: University of Colorado)
- Mideast Regional Birmingham–Jefferson Convention Complex, Birmingham, Alabama (Host: Southeastern Conference)
- East Regional Mellon Arena, Pittsburgh, Pennsylvania (Host: Duquesne University)
- West Regional Spokane Veterans Memorial Arena, Spokane, Washington (Host: Washington State University)
Bids by state
The sixty-four teams came from thirty-two states, plus Washington, D.C. Texas had the most teams with five bids. Eighteen states did not have any teams receiving bids.
|5||Texas||Stephen F. Austin, TCU, Baylor, Texas, Texas Tech|
|4||Tennessee||Austin Peay, Chattanooga, Tennessee, Vanderbilt|
|4||Virginia||Liberty, Old Dominion, Virginia, Virginia Tech|
|3||California||Saint Mary's, Stanford, UC Santa Barbara|
|3||Colorado||Colorado State, Colorado, Denver|
|3||Iowa||Iowa, Iowa State, Drake|
|3||Louisiana||Louisiana Tech, Tulane, LSU|
|3||Pennsylvania||Penn, Penn State, Villanova|
|2||District of Columbia||Howard, George Washington|
|2||Florida||Florida, Florida State|
|2||Georgia||Georgia, Georgia State|
|2||Indiana||Notre Dame, Purdue|
|2||Missouri||SW Missouri State, Missouri|
|2||New York||Long Island, Siena|
|2||North Carolina||Duke, NC State|
|2||Oklahoma||Oral Roberts, Oklahoma|
Mideast Regional - Birmingham, AL
|14||UC Santa Barbara||62|
|2||at Texas Tech||100|
West Regional - Spokane, Washington
|5||SW Missouri State||81|
|5||SW Missouri State||89|
|5||SW Missouri State||60|
|13||Stephen F. Austin||43|
|5||SW Missouri State||104|
Midwest Regional - Denver, Colorado
|1||at Notre Dame||98|
|2||at Iowa State||100|
East Regional - Pittsburgh, Pennsylvania
|4||at NC State||76|
|3||at Louisiana Tech||84|
Final Four - St. Louis, Missouri
|W5||SW Missouri State||64|
Record by conference
Fourteen conferences had more than one bid, or at least one win in NCAA Tournament play:
|Conference||# of Bids||Record||Win %||Round
Seventeen conferences went 0-1: America East, Big Sky Conference, Big South Conference, Big West Conference, Colonial, Horizon League, Ivy League, MAC, Mid-Continent, MEAC, Northeast Conference, Ohio Valley Conference, Patriot League, Southern Conference, Southland, SWAC, and Trans America
- Ruth Riley, Notre Dame
- Niele Ivey, Notre Dame
- Katie Douglas, Purdue
- Shalicia Hurns, Purdue
- Shereka Wright, Purdue 
- Dennis DeMayo (Semi-Final)
- Wesley Dean (Semi-Final)
- Nan Sisk (Semi-Final)
- June Courteau (Semi-Final)
- Greg Small (Semi-Final)
- Melissa Barlow (Semi-Final)
- Sally Bell (Final)
- Scott Yarbrough (Final)
- Lisa Mattingly (Final) 
- NCAA Women's Division I Basketball Championship
- 2001 NCAA Men's Division I Basketball Tournament
- 2001 NAIA Division I Men's Basketball Tournament
- Gregory Cooper. "2001 NCAA National Championship Tournament". Archived from the original on 2009-10-23. Retrieved 2007-04-17.
- "CHN Basketball History: Most Outstanding Player". Archived from the original on 2008-01-25. Retrieved 2007-04-17.
- Rodgers, Jenn. "2012-13 NCAA Women's Basketball Records Division I". NCAA. Archived from the original on 1 June 2013. Retrieved 27 May 2013.
- "Purdue handcuffs Stiles, SMS in 81-64 victory". The Florida Times Union. March 31, 2001. Retrieved 27 May 2013.
- "Notre Dame rallies to defeat Connecticut". CNN SI. March 31, 2001. Retrieved 27 May 2013.
- "Ruthless". CNN SI. April 1, 2001. Retrieved 27 May 2013.
- Nixon, Rick. "Official 2022 NCAA Women's Final Four Records Book" (PDF). NCAA. Retrieved 22 April 2012.
- "Attendance and Sites" (PDF). NCAA. Retrieved 19 March 2012.
- "Official 2012 NCAA Women's Final Four Records Book". NCAA. February 2012. Retrieved 2012-04-17.