|Duration||September 4 – December 19, 1988|
|Start date||December 24, 1988|
|AFC Champions||Cincinnati Bengals|
|NFC Champions||San Francisco 49ers|
|Super Bowl XXIII|
|Date||January 22, 1989|
|Site||Joe Robbie Stadium, Miami|
|Champions||San Francisco 49ers|
|Date||January 29, 1989|
The 1988 NFL season was the 69th regular season of the National Football League. The Cardinals relocated from St. Louis, Missouri to the Phoenix, Arizona area becoming the Phoenix Cardinals but remained in the NFC East division. The playoff races came down to the regular season's final week, with the Seattle Seahawks winning the AFC West by one game, and the Philadelphia Eagles and San Francisco 49ers winning their respective divisions in a five-way tie, with the New Orleans Saints and New York Giants losing the NFC Wild Card berth to the Los Angeles Rams on tiebreakers.
This season marked the final coaching season for the legendary Tom Landry.
- January 19, 1988: The Pittsburgh Steelers announce that Donnie Shell and John Stallworth have retired from professional football.
Johnny Grier became the first African-American in NFL history to be promoted to referee. Grier replaced long time referee Bob Frederic, who retired in the offseason. Grier was the field judge in the previous season's Super Bowl XXII, which was the same game that Doug Williams of the Washington Redskins became the first African-American quarterback to win the Super Bowl.
Major rule changes
- A standard system of two time intervals between plays are established (and would be timed using the play clock): For normal plays, the offensive team has 45 seconds to snap the ball after the previous play is signaled dead. After time outs and other administrative stoppages, the time limit is 30 seconds beginning after the Referee signals that the ball is ready to resume play.
- If a fumble occurs during an extra point attempt, only the fumbling player can recover and/or advance the ball. This change closes a loophole in the "Stabler Fumble Rule" that was enacted during the 1979 NFL season in reaction to the Holy Roller Game.
- The penalty for "Running into the kicker" is changed from five yards and a first down to just 5 yards.
- Referees were outfitted with white hats while all other officials wore black hats, which was the standard practice in college and high school football. From 1979 through 1987, referees wore black hats while all other officials wore white hats.
- Alan Ameche: Having played for the Baltimore Colts in the 1950s, he died of a heart attack on August 8, 1988 at age 55 at Methodist Hospital in Houston, Texas, a few days after undergoing another heart bypass surgery.
- Steve Chomyszak
- David Croudip: The Atlanta Falcons cornerback died on October 10 after a cocaine overdose. 
- Hall Haynes
- Clarke Hinkle
- Joe Don Looney
- Nick Pietrosante
- Bill Rooney
- Joey Sternaman
|Date||Winning Team||Score||Losing Team||Score||Stadium||City|
|July 31, 1988||Miami Dolphins||27||San Francisco 49ers||21||Wembley Stadium||London|
Highlights of the 1988 season included:
- Thanksgiving: Two games were played on Thursday, November 24, featuring Minnesota at Detroit and Houston at Dallas, with Minnesota and Houston winning.
- Cincinnati was the top AFC playoff seed ahead of Buffalo based on head-to-head victory (1–0).
- Indianapolis finished ahead of New England in the AFC East based on better record against common opponents (7–5 to Patriots’ 6–6).
- Cleveland finished ahead of Houston in the AFC Central based on better division record (4–2 to Oilers’ 3–3).
- San Francisco was the second NFC playoff seed ahead of Philadelphia on better record against common opponents (5–3 to Eagles’ 5–4).
- Philadelphia finished first in the NFC East based on head-to-head sweep of the N.Y. Giants (2–0).
- Washington finished third in the NFC East based on better division record (4–4) than Phoenix (3–5).
- Detroit finished fourth in the NFC Central based on head-to-head sweep of Green Bay (2–0).
- San Francisco finished first in the NFC West based on better head-to-head record (3–1) against the L.A. Rams (2–2) and New Orleans (1–3).
- The L.A. Rams finished second in the NFC West based on better division record (4–2) than New Orleans (3–3).
- Rams earned the #2 NFC Wild Card based on better conference record (8–4, .667) than the N.Y. Giants (9–5, .642) and New Orleans (6–6, .500).
NOTE: Rams-Giants-Saints conference record tiebreaker: best winning percentage (2nd figure shown in parenthesis) vs same-conference opponents. NY Giants had finished 5th in NFC East in 1987. Because of two then-existing situations, division alignment as well as team-vs-team scheduling, any 5th place team would in the following season play 14 in-conference and 2 out-of-conference teams. For 1st, 2nd, 3rd, 4th place teams, it would have been 12 in-conference and 4 out-of-conference teams. This was the NFL's reason for breaking ties in this type situation by percentage rather than by simple won-loss.
- NOTE: The Cincinnati Bengals (the AFC 1 seed) did not play the Houston Oilers (the 5 seed), nor did the Chicago Bears (the NFC 1 seed) play the Minnesota Vikings (the 4 seed), in the Divisional playoff round because those teams were in the same division.
|Jan. 1 – Rich Stadium|
|Dec. 24 – Cleveland Stadium||Jan. 8 – Riverfront Stadium|
|Dec. 31 – Riverfront Stadium|
|Jan. 22 – Joe Robbie Stadium|
|Wild Card playoffs||A1||Cincinnati||16|
|Jan. 1 – Candlestick Park|
|Super Bowl XXIII|
|Dec. 26 – Hubert H. Humphrey Metrodome||Jan. 8 – Soldier Field|
|5||LA Rams||17||2||San Francisco||28|
|Dec. 31 – Soldier Field|
|Points scored||Cincinnati Bengals (448)|
|Total yards gained||Cincinnati Bengals (6,057)|
|Yards rushing||Cincinnati Bengals (2,710)|
|Yards passing||Miami Dolphins (4,516)|
|Fewest points allowed||Chicago Bears (215)|
|Fewest total yards allowed||Minnesota Vikings (4,091)|
|Fewest rushing yards allowed||Chicago Bears (1,326)|
|Fewest passing yards allowed||Kansas City Chiefs (2,434)|
|Most Valuable Player||Boomer Esiason, Quarterback, Cincinnati|
|Coach of the Year||Mike Ditka, Chicago|
|Offensive Player of the Year||Roger Craig, Running back, San Francisco|
|Defensive Player of the Year||Mike Singletary, Linebacker, Chicago|
|Offensive Rookie of the Year||John Stephens, Running back, New England|
|Defensive Rookie of the Year||Erik McMillan, Safety, NY Jets|
|NFL Comeback Player of the Year||Greg Bell, Running Back, LA Rams|
|NFL Man of the Year||Steve Largent, Wide Receiver, Seattle|
|Super Bowl Most Valuable Player||Jerry Rice, Wide Receiver, San Francisco|
- Green Bay Packers: Forrest Gregg left to join the SMU Mustangs. Lindy Infante was named as Gregg's replacement.
- Los Angeles Raiders: Tom Flores stepped down to move to the team's front office. Mike Shanahan was named as the team's new head coach.
- Detroit Lions: Darryl Rogers was fired after 11 games and replaced by defensive coordinator Wayne Fontes.
- The Green Bay Packers removed the elliptical green circles with the player's number from the hip area of the pants, an addition made in 1984 by former coach Forrest Gregg.
- The San Diego Chargers switched to a darker shade of blue on their jerseys, from gold to blue face masks, and from gold to white lightning bolts. The helmets remained unchanged until a complete redesign in 2007.
- "Sports People; 2 Steelers Retire". New York Times. Retrieved December 3, 2020.
- "African-Americans in Pro Football". Pro Football Hall of Fame. Retrieved March 28, 2019.
- "Alan Ameche dies". The Hour. (Norwalk, Connecticut). Associated Press. August 9, 1988. p. 38.
- "Alan Ameche dies of heart problems". Reading Eagle. (Pennsylvania). news services. August 9, 1988. p. 13.
- "Falcon David Croudip Dies; Cocaine Cocktail Suspected". Los Angeles Times. October 10, 1988 – via Newspapers.com.