The 1968 United States Senate election in Alaska took place on November 5, 1968. Incumbent Democratic U.S. Senator Ernest Gruening ran for a second full term in office but finished behind Speaker of the Alaska House of Representatives Mike Gravel. Gruening launched an write-in bid for the seat in the general election, but finished third to Gravel and Republican former Anchorage mayor Elmer Rasmuson.
Gravel would later lose the primary in 1980 to Gruening's grandson Clark.
Future Senator Ted Stevens also ran in the primary, but lost to Rasmuson by around 1,000 votes. When incumbent Democratic Senator Bob Bartlett died that December, Governor Wally Hickel appointed Stevens to the vacant seat.
- Mike Gravel, former State Representative and Speaker of the Alaska House of Representatives from Anchorage
- Ernest Gruening, incumbent U.S. Senator since 1959
|Democratic||Ernest Gruening (incumbent)||16,015||47.1|
- Elmer Rasmuson, former Mayor of Anchorage and member of the University of Alaska Board of Regents
- Ted Stevens, State Representative and nominee for Senate in 1962
|Write-in||Ernest Gruening (incumbent)||14,118||17.44%|