|1946 San Francisco 49ers season|
|Head coach||Buck Shaw|
|Home field||Kezar Stadium|
|Division place||2nd AAFC West|
|Playoff finish||Did not qualify|
The 1946 San Francisco 49ers season was the inaugural season of the San Francisco 49ers and the first season of the All-America Football Conference. Led by head coach Buck Shaw, the team compiled a 9–5 record and finished second in the AAFC West Division. The 49ers also had the second best scoring offense (307 points scored) in the AAFC.
The team's statistical leaders included quarterback Frankie Albert with 1,404 passing yards, fullback Norm Standlee with 651 rushing yards, and end Alyn Beals with 586 receiving yards and 61 points scored.
|August 24||Los Angeles Dons at San Diego||W 17–7||1–0|
|September 1||Chicago Rockets||W 34–14||2–0|
|1||September 8||New York Yankees||L 7–21||0–1||Kezar Stadium||Recap|
|2||September 15||Miami Seahawks||W 21–14||1–1||Kezar Stadium||Recap|
|3||September 22||Brooklyn Dodgers||W 32–13||2–1||Kezar Stadium||Recap|
|4||September 29||at Chicago Rockets||L 7–24||2–2||Soldier Field||Recap|
|5||October 8||at Miami Seahawks||W 34–7||3–2||Burdine Stadium||Recap|
|6||October 12||at Los Angeles Dons||W 23–14||4–2||Los Angeles Memorial Coliseum||Recap|
|7||October 19||at Buffalo Bisons||L 14–17||4–3||Civic Stadium||Recap|
|8||October 27||at Cleveland Browns||W 34–20||5–3||Cleveland Municipal Stadium||Recap|
|9||November 2||Buffalo Bisons||W 27–14||6–3||Kezar Stadium||Recap|
|10||November 10||Cleveland Browns||L 7–14||6–4||Kezar Stadium||Recap|
|11||November 17||at New York Yankees||L 9–10||6–5||Yankee Stadium||Recap|
|12||November 24||at Brooklyn Dodgers||W 30–14||7–5||Ebbets Field||Recap|
|13||November 30||Chicago Rockets||W 14–0||8–5||Kezar Stadium||Recap|
|14||December 8||Los Angeles Dons||W 48–7||9–5||Kezar Stadium||Recap|
Note: Intra-division opponents are in bold text.
|San Francisco 49ers||9||5||0||.643||307||189||W-3|
|Los Angeles Dons||7||5||2||.583||305||290||T-1|
Players shown in bold started at least one game at the position listed as confirmed by contemporary game coverage.
|San Francisco 49ers 1946 roster|