|Duration||September 13 – December 13, 1942|
|East Champions||Washington Redskins|
|West Champions||Chicago Bears|
The Chicago Bears finished the regular season at 11–0, and faced the 10–1 Washington Redskins in the championship game. Washington, which had been beaten 73–0 in the 1940 title game, got a measure of revenge in spoiling the Bears' hope for a perfect season, winning 14–6.
Major rule changes
- The use of flags on flexible shafts to mark the intersections of goal lines and side lines (the predecessor to the pylon) becomes mandatory.
- A clarification to the offsides rule is added: The center or snapper is not offsides unless a portion of his body is ahead of the defensive team's line.
- A half cannot end on a double foul. Instead, the period will be extended by one untimed down.
- Detachable kicking toes are prohibited.
- When an encroachment or false start causes the other team to be offsides, only the initial foul is penalized.
- A forward pass that first touches an ineligible receiver may be intercepted.
- If the offensive team commits pass interference in their opponent's end zone, it is an automatic touchback.
|NFL Eastern Division|
|New York Giants||5||5||1||.500||4–4||155||139||W2|
Note: Tie games were not officially counted in the standings until 1972.
|NFL Western Division|
|Green Bay Packers||8||2||1||.800||6–2||300||215||W2|
NFL Championship Game
|Passing||Cecil Isbell||Green Bay||2021|
|Receiving||Don Hutson||Green Bay||1211|
|Joe F. Carr Trophy (Most Valuable Player)||Don Hutson, Wide receiver, Green Bay|
- Brooklyn Dodgers: Jock Sutherland was replaced by Mike Getto.
- Chicago Bears: George Halas stepped down after five games in 1942 to serve in the U.S. Navy during World War II. In his place, Hunk Anderson and Luke Johnsos served as co-coaches of the Bears.
- Detroit Lions: Bill Edwards was released after three games in 1942. John Karcis served for the final eight games.
- The Cleveland Rams moved from Cleveland Municipal Stadium to League Park
- The Philadelphia Eagles moved back from Philadelphia Municipal Stadium to Shibe Park, where they played in 1940