The 1922 United States Senate elections in Arizona took place on November 3, 1922. Incumbent Democratic U.S. Senator Henry F. Ashurst ran for reelection to a third term, defeating Republican nominee James Harvey McClintock in the general election by a wide margin.
- Henry F. Ashurst, incumbent U.S. Senator
- James Harvey McClintock, State Historian
|Democratic||Henry F. Ashurst||39,722||65.03%|
|Republican||James Harvey McClintock||21,358||34.97%|
|Democratic gain from Republican||Swing|