This article presents lists of the literary events and publications in 1621.
- January 27 – Sir Francis Bacon is created Viscount St Alban.[a]
- February 3 – John Chamberlain writes to Sir Dudley Carleton telling him the anonymous author of the tract Vox Populi has been revealed to be the radical preacher Thomas Scott.
- May 3 – Sir Francis Bacon is imprisoned in the Tower of London after being tried and convicted of receiving bribes; he is pardoned by King James I later in the year.
- August 26 – Barten Holyday's allegorical play Technogamia, originally produced at Christ Church, Oxford in 1618, is staged before King James at Woodstock Palace. (James dislikes it, but is persuaded to stay to the end for the student actors' sakes.)
- September 24 – The earliest known copy of the Corante, generally regarded as the first English newspaper, is published.
- November 22 – The English poet John Donne is installed as Dean of St Paul's Cathedral in London.
- December 30 – The Spanish writer Francisco de Borja y Aragón is replaced as Viceroy of Peru by Juan Jiménez de Montalvo, and embarks for home on the following day.
- During the year – Jeremias Drexel gives up preaching in order to write a biography of Elisabeth of Lorraine.
- William Alabaster – De bestia Apocalypsis
- Robert Burton – The Anatomy of Melancholy
- Méric Casaubon – Pietas contra maledicos patrii Nominis et Religionis Hostes
- Mao Yuanyi (茅元儀, editor) – Wubei Zhi (武備志, Treatise on Armaments)
- John Reynolds – The triumphs of Gods revenge, against the crying, and execrable sinne of murther
- Rachel Speght – Mortalities Memorandum
- John Taylor – Taylor's Motto
- John Widdowes – A Description of the World
- Lady Mary Wroth – The Countess of Montgomery's Urania
- Francis Beaumont, John Fletcher, & Philip Massinger – Thierry and Theodoret (published)
- Thomas Dekker, John Ford, & William Rowley – The Witch of Edmonton
- Ben Jonson – The Gypsies Metamorphosed
- Tirso de Molina – El vergonzoso en palacio
- George Wither – Wither's Motto
- January 27 – Thomas Willis, English physician and natural philosopher (died 1675)
- March 18 – Henry Teonge, English diarist and naval chaplain (died 1690)
- March 31 – Andrew Marvell, English poet (died 1678)
- April 25 – Roger Boyle, 1st Earl of Orrery, Anglo-Irish dramatist (died 1679)
- July 8 – Jean de La Fontaine, French author of fables (died 1695)
- December 3 – Bohuslav Balbín, Czech Jesuit writer (died 1688)
- December 14 (baptised) – Thomas Long, English writer and cleric (died 1707)
- Unknown dates
- Uncertain year (1621 or 1622)
- March 4 – Ana de Jesús, Spanish nun and writer (born 1545)
- May 11 – Johann Arndt, German theologian (born 1555)
- June – William Strachey, English eye-witness historian (born 1572)
- August 3 – Guillaume du Vair, French writer (born 1556)
- August 15 – John Barclay, Scottish writer (born 1582)
- September 25 – Mary Sidney, English playwright and translator (born 1561)
- October 7 or 8 – Antoine de Montchrestien, French adventurer and dramatist (born c. 1575)
- December 4 – Andrew Willet, English polemicist and cleric (born 1562)
- Unknown dates
- Fowler (1885), p. 346. Harv error: no target: CITEREFFowler1885 (help)
- EB (1911), p. 135. Harv error: no target: CITEREFEB1911 (help)
- Peltonen (2007). Harv error: no target: CITEREFPeltonen2007 (help)
- EB (1878), p. 200. Harv error: no target: CITEREFEB1878 (help)
- Williams, Hywel (2005). Cassell's Chronology of World History. London: Weidenfeld & Nicolson. ISBN 0-304-35730-8.
- Some sources, such as the Dictionary of National Biography (1885) and the 11th edition of the Encyclopædia Britannica, spell the title as "St. Albans"; others, such as the 2007 Oxford Dictionary of National Biography and the 9th edition of the Encyclopædia Britannica, spell it "St. Alban".