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|Ab urbe condita||2233|
|Balinese saka calendar||1401–1402|
|English Regnal year||19 Edw. 4 – 20 Edw. 4|
|Chinese calendar||己亥年 (Earth Pig)|
4176 or 4116
— to —
庚子年 (Metal Rat)
4177 or 4117
|- Vikram Samvat||1536–1537|
|- Shaka Samvat||1401–1402|
|- Kali Yuga||4580–4581|
|Japanese calendar||Bunmei 12|
|Minguo calendar||432 before ROC|
|Thai solar calendar||2022–2023|
1606 or 1225 or 453
— to —
1607 or 1226 or 454
|Wikimedia Commons has media related to 1480.|
- March 6 – Treaty of Toledo: Ferdinand and Isabella of Spain recognize the African conquests of Afonso V of Portugal, and he cedes the Canary Islands to Spain (see Treaty of Alcáçovas).
- July 28
- August 12 - Ottoman invasion of Otranto: Ottoman troops behead 800 Christians for refusing to convert to Islam. The Martyrs of Otranto are canonized in 2013.
- September 27 – Consorts and co-rulers Ferdinand II of Aragon and Isabella I of Castile initiate the Spanish Inquisition (looking for heretics and unconverted Jews).
- October – Great Stand on the Ugra River: Muscovy becomes independent from the Golden Horde. The Theotokos of Vladimir icon is credited with saving Moscow.
- The Lighthouse of Alexandria's final remains disappear when Qaitbay, Sultan of Egypt, builds the Citadel of Qaitbay on its site.
- Magdalen College School, Oxford, is established by William Waynflete.
- January 10 – Margaret of Austria, Regent of the Netherlands (d. 1530)
- February 12 – Frederick II of Legnica, Duke of Legnica from 1488 (until 1495 and 1505 with his brothers) (d. 1547)
- February 13 – Girolamo Aleandro, Italian Catholic cardinal (d. 1542)
- April 10 – Philibert II, Duke of Savoy (d. 1504)
- April 18 – Lucrezia Borgia, Duchess of Ferrara (d. 1519)
- June 1 – Tiedemann Giese, Catholic bishop from Danzig (Gdańsk) in Poland (d. 1550)
- July 5 – Philip of the Palatinate, Bishop of Freising and Naumburg (d. 1541)
- October 1 – Saint Cajetan, Italian Catholic priest and religious reformer (d. 1547)
- November 10 – Bridget of York, English nun (d. 1517)
- October – Saint Cajetan, founder of the Theatines (d. 1547)
- date unknown
- Fernão de Magalhães, Portuguese navigator (d. 1521)
- Vannoccio Biringuccio, Italian metallurgist (d. 1539)
- Claude Garamond, French publisher (d. 1561)
- Giovanni Guidiccioni, Italian poet (d. 1541)
- Ferdinand Magellan, Portuguese explorer (d. 1521)
- Jerzy Radziwiłł, Polish nobleman (d. 1541)
- Gazi Husrev-beg, Ottoman statesmen (d. 1541)
- Palma il Vecchio, Italian painter (d. 1528)
- Arasibo, Taino Cacique
- Hans Baldung, German painter (d. 1545)
- Matteo Bandello, Italian novelist (d. 1562)
- Johann Georg Faust, German alchemist (d. 1540)
- Anna Taskomakare, Swedish merchant craftswoman and estate owner (d. after 1528)
- Jumacao, Taino Cacique
- Conn O'Neill, 1st Earl of Tyrone (d. 1559)
- Marcantonio Raimondi, Italian engraver (d. c. 1534)
- Alix Tammy Sutherland, Scottish Pirate (d. 1539)
- January 5 – Jakobus, nobleman from Lichtenberg in the northern part of Alsace (b. 1416)
- April 14 – Thomas de Spens, Scottish statesman and prelate (b. c. 1415)
- May 10 – Philipp I, Count of Hanau-Lichtenberg (1458–1480) (b. 1417)
- May 19 – Jan Długosz, Polish historian (b. 1415)
- May 25 – William III, Count of Henneberg-Schleusingen (b. 1434)
- June 6 – Vecchietta, Italian painter, sculptor and architect (b. c. 1410)
- July 6 – Antonio Squarcialupi, Italian composer (b. 1416)
- July 10 – René of Anjou, king of Naples (b. 1409)
- July 15 – John III, Count of Nassau-Weilburg, German nobleman (b. 1441)
- July 26 – Ruprecht of the Palatinate, Archbishop and Prince Elector of Cologne (b. 1427)
- September 1 – Ulrich V, Count of Württemberg (b. 1413)
- October 4 – Jakub of Sienno, medieval Bishop Kraków in the years 1461–1463 (b. 1413)
- October 18 – Uhwudong, Korean dancer (b. 1440)
- November 20 – Eleanor of Scotland, Scottish princess (b. 1433)
- November 29 – Frederick I, Count Palatine of Simmern (b. 1417)
- December 14 – Niccolò Perotti, Italian humanist scholar (b. 1429)
- date unknown
- Hourihane, Colum (2012). The Grove Encyclopedia of Medieval Art and Architecture. OUP USA. p. 396. ISBN 9780195395365.
- Levin, Carole; Bertolet, Anna Riehl; Carney, Jo Eldridge (2016). A Biographical Encyclopedia of Early Modern Englishwomen: Exemplary Lives and Memorable Acts, 1500-1650. Taylor & Francis. p. 276. ISBN 9781315440712.
- "René I | duke of Anjou". Encyclopedia Britannica. Retrieved May 10, 2019.