|Ab urbe condita||2203|
|Balinese saka calendar||1371–1372|
|English Regnal year||28 Hen. 6 – 29 Hen. 6|
|Chinese calendar||己巳年 (Earth Snake)|
4146 or 4086
— to —
庚午年 (Metal Horse)
4147 or 4087
|- Vikram Samvat||1506–1507|
|- Shaka Samvat||1371–1372|
|- Kali Yuga||4550–4551|
|Japanese calendar||Hōtoku 2|
|Minguo calendar||462 before ROC|
|Thai solar calendar||1992–1993|
1576 or 1195 or 423
— to —
1577 or 1196 or 424
|Wikimedia Commons has media related to 1450.|
- February 7 – John de la Pole, 2nd Duke of Suffolk, marries Lady Margaret Beaufort.
- February 26 – Francesco Sforza enters Milan after a siege, becoming Duke of the city-state and, founding a dynasty that will rule Milan for a century.
- March – French troops under Guy de Richemont besiege the English commander in France, Edmund Beaufort, 1st Duke of Somerset, in Caen.
- April 15 – Battle of Formigny: French troops under the Comte de Clermont defeat an English army under Sir Thomas Kyriel and Sir Matthew Gough, which was attempting to relieve Caen.
- May 8 – Jack Cade's Rebellion: Kentishmen revolt against King Henry VI of England.
- May 9 – Abdal-Latif Mirza, a Timurid dynasty monarch, is assassinated.
- May 13 – Charles VIII of Sweden, also serving as Carl I of Norway, is declared deposed from the latter throne, in favor of Christian I of Denmark.
- June 18 – Battle of Seven Oaks: Jack Cade's rebels are driven from London by loyal troops, bringing about the collapse of the rebellion.
- July 6 – Caen surrenders to the French.
- July 12 – Jack Cade is slain in a skirmish.
- August 12 – Cherbourg, the last English territory in Normandy, surrenders to the French.
- October 5 – Jews are expelled from Lower Bavaria, by order of Duke Ludwig IX.
- November 3 – The University of Barcelona is founded.
- November 23 – First Siege of Krujë: Albanian troops are victorious, forcing an Ottoman army of approximately 100,000 men to retreat from Albania.
- Machu Picchu (Quechua: Machu Pikchu, "Old mountain"), a pre-Columbian Inca site located 2,400 meters (7,875 ft) above sea level, is believed to be under construction.
- A religious sacrifice of over a hundred children was performed around this time, outside of the ancient city of Chan Chan (near modern Trujillo), on the north coast of Peru.
- Johannes Gutenberg has set up his movable type printing press, as a commercial operation in Mainz, by this date.
- February 12 – Yejong of Joseon, Joseon King (d. 1469)
- May 18 – Piero Soderini, Florentine statesman (d. 1513)
- June 22 – Eleanor of Naples, Duchess of Ferrara (d. 1493)
- July 25 – Jakob Wimpfeling, Renaissance humanist (d. 1528)
- August 18 – Marko Marulić, Croatian poet (d. 1524)
- September 25 – Ursula of Brandenburg, Duchess of Münsterberg-Oels and Countess of Glatz (d. 1508)
- November 12 – Jacques of Savoy, Count of Romont, Prince of Savoy (d. 1486)
- date unknown
- Kamāl ud-Dīn Behzād, Persian leader of the Herat school
- Hieronymus Bosch, Dutch painter (d. 1516)
- Gaspar Corte-Real, Portuguese explorer (d. 1501)
- Juan de la Cosa, Spanish navigator and cartographer (d. 1510)
- Josquin des Prez, Dutch composer (d. 1521)
- Heinrich Isaac, Franco-Flemish composer (d. 1517)
- Hugh Oldham, Bishop of Exeter (d. 1519)
- Pietro Antonio Solari, Italian architect (d. 1493)
- Petrus Thaborita, Dutch historian and monk (d. 1527)
- January 9 – Adam Moleyns, Bishop of Chichester
- February 9 – Agnès Sorel, mistress of Charles VII of France (b. 1421)
- April 8 – Sejong the Great of Joseon, ruler of Korea (b. 1397)
- May 2 – William de la Pole, 1st Duke of Suffolk, English military leader (born 1396)
- May 9 – 'Abd al-Latif, ruler of Transoxania
- July 2 – Ranuccio Farnese il Vecchio, Italian condottiero (b. c. 1390)
- July 4 – James Fiennes, 1st Baron Saye and Sele
- July 18 – Francis I, Duke of Brittany (b. 1414)
- July 26 – Cecily Neville, Duchess of Warwick (b. 1424)
- August 15 – Alberto da Sarteano, Italian Franciscan friar and papal legate (b. 1385)
- August 27 – Reginald West, 6th Baron De La Warr, English politician (b. 1395)
- August 31 – Isabella of Navarre, Countess of Armagnac (b. 1395)
- September 16 – Louis Aleman, French cardinal
- September 22 – William Tresham, English politician
- October 1 – Leonello d'Este, Marquis of Ferrara, Italian noble (b. 1407)
- November 3 – Paola Colonna, Lady of Piombino (b. c. 1378)
- November 5 – John IV, Count of Armagnac (b. 1396)
- "Historic Sanctuary of Machu Picchu — UNESCO World Heritage Centre". UNESCO. 2006. Retrieved December 9, 2006.
- Klooster, John W. (2009). Icons of invention: the makers of the modern world from Gutenberg to Gates. Santa Barbara, CA: ABC-CLIO. p. 8. ISBN 978-0-313-34745-0.